Investing.com – U.S. stocks were lower after the close on Wednesday, as losses in the , and sectors led shares lower.

At the close in NYSE, the declined 0.12%, while the index fell 0.58%, and the index lost 1.15%.

The best performers of the session on the were UnitedHealth Group Incorporated (NYSE:), which rose 2.13% or 9.98 points to trade at 478.87 at the close. Meanwhile, Goldman Sachs Group Inc (NYSE:) added 1.80% or 7.14 points to end at 404.00 and McDonald’s Corporation (NYSE:) was up 1.67% or 4.44 points to 269.87 in late trade.

The worst performers of the session were The Travelers Companies Inc (NYSE:), which fell 7.37% or 16.45 points to trade at 206.67 at the close. Intel Corporation (NASDAQ:) declined 1.60% or 0.58 points to end at 35.68 and Amazon.com Inc (NASDAQ:) was down 1.11% or 2.04 points to 181.28.

The top performers on the S&P 500 were United Airlines Holdings Inc (NASDAQ:) which rose 17.45% to 48.74, American Airlines Group (NASDAQ:) which was up 6.60% to settle at 13.89 and Globe Life Inc (NYSE:) which gained 5.39% to close at 63.20.

The worst performers were JB Hunt Transport Services Inc (NASDAQ:) which was down 8.12% to 168.13 in late trade, The Travelers Companies Inc (NYSE:) which lost 7.37% to settle at 206.67 and Prologis Inc (NYSE:) which was down 7.18% to 106.50 at the close.

The top performers on the NASDAQ Composite were INVO Bioscience Inc (NASDAQ:) which rose 133.33% to 1.82, SINTX Technologies Inc (NASDAQ:) which was up 63.60% to settle at 0.04 and WiSA Technologies Inc (NASDAQ:) which gained 51.64% to close at 9.25.

The worst performers were Iczoom Group Inc (NASDAQ:) which was down 88.26% to 5.99 in late trade, Sunshine Biopharma Inc (NASDAQ:) which lost 44.12% to settle at 3.80 and Dare Bioscience Inc (NASDAQ:) which was down 41.70% to 0.28 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 1509 to 1307 and 88 ended unchanged; on the Nasdaq Stock Exchange, 2129 fell and 1210 advanced, while 143 ended unchanged.

Shares in Sunshine Biopharma Inc (NASDAQ:) fell to 52-week highs; down 44.12% or 3.00 to 3.80. Shares in Dare Bioscience Inc (NASDAQ:) fell to all time lows; down 41.70% or 0.20 to 0.28.

The , which measures the implied volatility of S&P 500 options, was down 1.03% to 18.21.

Gold Futures for June delivery was down 0.85% or 20.35 to $2,387.45 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in May fell 2.99% or 2.55 to hit $82.81 a barrel, while the June Brent oil contract fell 2.83% or 2.55 to trade at $87.47 a barrel.

EUR/USD was up 0.53% to 1.07, while USD/JPY fell 0.20% to 154.40.

The US Dollar Index Futures was down 0.28% at 105.76.

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